25 papers
The FAXAge study is a 52-week randomized controlled trial investigating whether time-restricted feeding, exercise, or their combination can slow biological aging in adults over 65 by measuring changes in DNA methylation clocks and other multi-omics biomarkers.
This study developed and validated a multi-trait polygenic score for intrinsic capacity using data from over 13,000 Canadian participants, demonstrating that a model integrating genetic predictors across five domains effectively captures the multisystem biological basis of healthy aging and is significantly associated with reduced mortality.
This study found that while approximately one-fifth of community-dwelling older adults exhibit vestibular agnosia, which is independently associated with poorer balance, elevated vestibular perceptual thresholds do not predict prospective falls over a six-month period.
This study utilizing data from 4,290 older adults demonstrates that while patient reports are the standard for subjective cognitive decline (SCD), incorporating informant and clinician perspectives provides distinct and valuable insights into cognitive status and decline across normal aging, mild cognitive impairment, and Alzheimer's disease.
This randomized sham-controlled trial demonstrates that a personalized 15-day high-dose accelerated intermittent theta-burst stimulation (aiTBS) protocol targeting either the default mode or fronto-parietal network significantly improves cognitive function in patients with mild Alzheimer's disease, with benefits sustained at three months.