32 papers
Geriatric medicine focuses on the unique health needs of older adults, addressing complex conditions that often arise as we age. This field goes beyond treating single diseases to manage the whole person, considering how multiple chronic issues, medication interactions, and physical changes affect quality of life. By prioritizing functional ability and dignity, researchers in this space aim to help people live healthier, more independent lives for as long as possible.
Gist.Science makes the latest findings in this vital area accessible by processing every new preprint from medRxiv in this category. We transform these raw scientific reports into both plain-language overviews for general readers and detailed technical summaries for specialists, ensuring no one is left behind by complex jargon. Below are the latest papers in geriatric medicine, updated regularly as new research becomes available on medRxiv.
This study utilizes a generator-matrix causal-inference framework to demonstrate that the majority of human mortality acceleration is driven by latent dynamics largely invisible to current measurable biomarkers, which show no causal effect on lifespan and remain resistant to cellular reprogramming.
This cross-sectional study of the FREEDOM cohort reveals that cognitive impairment is highly prevalent and strongly associated with physical frailty and functional dependence in community-dwelling older adults, with modifiable risk factors such as low BMI, hypertension, alcohol consumption, smoking, and polypharmacy identified as key predictors of poor cognitive performance.
This study leverages CHARLS data to develop a dynamic nomogram integrating routine blood markers and mental health indicators, revealing that depression is a dominant predictor of disability in elderly cardiometabolic multimorbidity patients and that the risk relationship plateaus after three comorbidities.
This study demonstrates that a bagging classifier machine learning model, trained on a population-based dataset from Hospital Universitario Parc Tauli, can effectively and proactively identify patients with advanced chronic conditions (MACA) with high sensitivity (0.91) and AUC (0.90) using ten key clinical and functional predictors.
This qualitative study reveals that older adults with heart failure redefine aging well by prioritizing physical and cognitive function, social relationships, and pain avoidance over disease absence, with specific priorities shaped by their neighborhood's socioeconomic context.
This study developed and validated a reliable, feasible, and sensitive video-based rating instrument to assess safe indoor wheeled walker use in frail older adults, demonstrating strong agreement with nursing staff evaluations and the ability to detect improvements following rehabilitation.
This study of older HIV-positive Veterans demonstrates that the VACS 2.0 Frailty Index correlates with medication burden and strongly associates with soluble TNF receptor levels, suggesting a potential link between systemic inflammation and frailty that warrants further mechanistic investigation.
This manuscript, which investigated the relationship between oxidative balance score and osteoarthritis using NHANES, RNA-seq, and Mendelian randomization, has been formally withdrawn by the authors due to a fundamental flaw in the study design where the reliance on unverified self-reported diagnoses introduced substantial misclassification bias that invalidates the core findings.
This pilot study demonstrates that replacing 16 to 26 liters of blood plasma in patients with mild cognitive impairment and Alzheimer's biomarkers with plasma from young, healthy donors is a safe and feasible procedure, supporting further investigation into its potential to delay cognitive deterioration through interstitial fluid rejuvenation.
By utilizing a new metric called Distance of Covariance (DISCO), this study demonstrates that human aging is characterized by a systemic increase in entropy that spreads across interconnected organ networks, suggesting that aging is a failure of integrated homeostatic coordination rather than a collection of independent organ-specific processes.